WEDNESDAY, Sept. 4, 2019 (HealthDay Information) — Greater ranges of the mind chemical serotonin are linked to a decrease threat of doubtless lethal seizure-related breathing pauses in individuals with epilepsy, researchers say.
The findings recommend serotonin might assist shield individuals with epilepsy from this risk, based on the authors of the examine printed within the Sept. Four on-line problem of the journal Neurology.
“Serotonin, a hormone that transmits alerts between nerve cells within the mind, is understood to control respiratory and waking from sleep, however what’s unknown is the way it might affect respiratory earlier than, throughout and after seizures,” examine creator Dr. Samden Lhatoo stated in a journal information launch.
Lhatoo is a professor of neurology on the College of Texas’ McGovern Medical College in Houston.
“Our findings present that greater ranges of serotonin after a seizure are related to much less respiratory dysfunction, and whereas we can’t make any hyperlinks between serotonin ranges and a threat of sudden unexplained demise in epilepsy [SUDEP], our analysis might present some vital clues, since SUDEP has been linked in earlier analysis to profound respiratory dysfunction after generalized convulsive seizures,” stated Lhatoo, who carried out the analysis at Case Western Reserve College in Cleveland.
The examine included 49 sufferers, common age 42, with hard-to-treat epilepsy. Whereas in an epilepsy monitoring unit, electrical exercise of their mind and coronary heart, blood-oxygen ranges, and adjustments in blood stream had been assessed throughout an epileptic seizure.
To measure serotonin ranges, blood samples had been collected inside about 10 minutes of a seizure and once more not less than 12 hours later.
In all, 35% of sufferers briefly stopped respiratory throughout seizures and 30% briefly stopped respiratory afterward.
Serotonin ranges after a seizure had been greater than earlier than it in sufferers who didn’t briefly cease respiratory both throughout or after the occasion. Amongst sufferers who did briefly cease respiratory, serotonin ranges weren’t considerably greater earlier than or after a seizure.
“Our outcomes give new perception right into a doable hyperlink between serotonin ranges and respiratory throughout and after seizure,” Lhatoo stated.
He stated this provides hope that new therapies might be developed sooner or later to assist stop sudden unexplained demise in epilepsy. However, he added, the present examine was small and extra analysis is required to verify the findings.
“Additionally it is vital to notice that extra serotonin may be dangerous, so we strongly suggest towards anybody looking for methods to extend their serotonin ranges in response to our examine findings,” Lhatoo concluded.
— Robert Preidt
Copyright © 2019 HealthDay. All rights reserved.
SOURCE: Neurology, information launch, Sept. 4, 2019